Natural product discovery through microbial genome mining
نویسندگان
چکیده
منابع مشابه
Microbial genomics for the improvement of natural product discovery.
The quest for the discovery of novel natural products has entered a new chapter with the enormous wealth of genetic data that is now available. This information has been exploited by using whole-genome sequence mining to uncover cryptic pathways, or biosynthetic pathways for previously undetected metabolites. Alternatively, using known paradigms for secondary metabolite biosynthesis, genetic in...
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Small-molecule secondary metabolites isolated from microorganisms and plants provide the chemical scaffolds of a large fraction of today’s pharmaceuticals. Evolutionary forces shaped the molecular complexity of these natural products that contribute to the exquisite binding of these compounds to biological targets. Starting with the discovery of penicillin by Fleming, we have seen a rapid incre...
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The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysin...
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A t the beginning of the genomic revolution, genomes were frequently described as the instruction manuals for an organism, but as the revolution progressed, many of these genomic instruction manuals resembled the frustratingly opaque descriptions that accompany so many new household gadgets, laboratory devices, and computer software. An important exception to this opacity has been in microbial ...
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Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently ge...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2021
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2020.07.010